Developing a new laser technology to map the mechanical properties of tissue
An optical approach to 3-dimensional micro-mechanical imaging of the extra-cellular matrix (ECM)
This study is testing a new laser technology that helps scientists see and understand the structure of tissues in the body, which can change when diseases are present, to improve how we diagnose and treat these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Lowell NIH-funded |
| Lab location | 1 site (Lowell, United States) |
| Project ID | NIH-10895055 on NIH RePORTER |
What this research studies
This research aims to create and validate a novel laser-based technology called Speckle Field Microrheology (SLIM) for detailed imaging of the extracellular matrix (ECM) in tissues. By measuring how light interacts with the ECM, this technology can provide insights into the stiffness and mechanical properties of tissues, which are crucial for understanding various diseases. The approach focuses on capturing the dynamic behavior of particles within the ECM, allowing researchers to visualize changes that may indicate disease progression. This could lead to better diagnostic tools and treatment strategies for conditions linked to ECM remodeling.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with conditions associated with abnormal ECM remodeling, such as cancer, cardiovascular diseases, or fibrotic disorders.
Not a fit: Patients with conditions unrelated to ECM stiffness or those who do not have any tissue remodeling issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and treatment options for diseases related to tissue stiffness, such as cancer and cardiovascular disorders.
How similar studies have performed: While the specific SLIM technology is novel, similar imaging techniques have shown promise in understanding tissue mechanics and disease progression.
Where this research is happening
Lowell, United States
- University of Massachusetts Lowell — Lowell, United States (Active)
Researchers
- Principal investigator: Hajjarian, Zeinab — University of Massachusetts Lowell
- Study coordinator: Hajjarian, Zeinab
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.