Developing a new imaging technique to measure molecular chirality
Instrument development for vibrational circular dichroism imaging
This study is working on a new type of microscope that uses special light to look at the tiny structures in our body, helping us understand how molecules behave in health and disease, which could lead to better treatments for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project ID | NIH-10844585 on NIH RePORTER |
What this research studies
This research focuses on creating a novel imaging instrument that utilizes Vibrational Circular Dichroism (VCD) spectroscopy to measure molecular chirality in biological tissues. By building a custom quantum cascade laser microscope, the researchers aim to overcome technological challenges that have previously limited the ability to image chirality. The approach involves rapidly acquiring spectra across various wavelengths, allowing for detailed mapping of chirality in samples. This could enhance our understanding of molecular interactions in health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals with conditions related to molecular chirality, such as certain cancers or neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to molecular chirality or those who do not have access to the imaging technology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools for various diseases by enabling precise measurements of molecular structures.
How similar studies have performed: While VCD spectroscopy has been used in homogeneous materials, this approach to imaging is novel and has not been extensively tested in clinical settings.
Where this research is happening
Champaign, United States
- University of Illinois at Urbana-Champaign — Champaign, United States (Active)
Researchers
- Principal investigator: Bhargava, Rohit — University of Illinois at Urbana-Champaign
- Study coordinator: Bhargava, Rohit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.