Developing a new imaging system to study protein interactions in live cells
Building a lightsheet system with dual-color fluorescence anisotropy capability for mapping protein-protein interactions in live cells
['FUNDING_R03'] · MARINE BIOLOGICAL LABORATORY · NIH-11056896
This study is working on a new way to take clear pictures of how proteins interact in living cells without harming them, which could help us learn more about important biological processes.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MARINE BIOLOGICAL LABORATORY (nih funded) |
| Locations | 1 site (WOODS HOLE, UNITED STATES) |
| Trial ID | NIH-11056896 on ClinicalTrials.gov |
What this research studies
This research focuses on creating an advanced imaging system that combines lightsheet microscopy with dual-color fluorescence anisotropy to observe protein-protein interactions in live cells. By utilizing this innovative approach, researchers aim to achieve high-resolution imaging while minimizing damage to the cells. The methodology involves designing a specialized optical splitter and using advanced camera technology to capture detailed images of cellular interactions, which could enhance our understanding of biological processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve protein interactions, such as cancer or neurodegenerative diseases.
Not a fit: Patients with stable, non-progressive conditions that do not involve protein interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in our understanding of cellular mechanisms and disease processes, potentially informing new therapeutic strategies.
How similar studies have performed: Previous research has shown promise in using fluorescence anisotropy for studying protein interactions, indicating that this approach could yield valuable insights.
Where this research is happening
WOODS HOLE, UNITED STATES
- MARINE BIOLOGICAL LABORATORY — WOODS HOLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARENT, MATTHEW T — MARINE BIOLOGICAL LABORATORY
- Study coordinator: PARENT, MATTHEW T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.