Developing a new imaging system to study protein interactions in live cells
Official title: Building a lightsheet system with dual-color fluorescence anisotropy capability for mapping protein-protein interactions in live cells
Funded at Marine Biological Laboratory · NIH-11056896 · Data updated 2026-11-12
This study is working on a new way to take clear pictures of how proteins interact in living cells without harming them, which could help us learn more about important biological processes.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marine Biological Laboratory NIH-funded |
| Lab location | 1 site (Woods Hole, United States) |
| Project start | March 15, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $85,750 |
| NIH project number | 5R03EB035329-02 |
| Project ID | NIH-11056896 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve protein interactions, such as cancer or neurodegenerative diseases.
✕Less likely to help
Patients with stable, non-progressive conditions that do not involve protein interactions may not benefit from this research.
What this research studies
This research focuses on creating an advanced imaging system that combines lightsheet microscopy with dual-color fluorescence anisotropy to observe protein-protein interactions in live cells. By utilizing this innovative approach, researchers aim to achieve high-resolution imaging while minimizing damage to the cells. The methodology involves designing a specialized optical splitter and using advanced camera technology to capture detailed images of cellular interactions, which could enhance our understanding of biological processes.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in our understanding of cellular mechanisms and disease processes, potentially informing new therapeutic strategies.
How similar studies have gone: Previous research has shown promise in using fluorescence anisotropy for studying protein interactions, indicating that this approach could yield valuable insights.
Where this research is happening
-
Marine Biological Laboratory
Woods Hole, United States Active
Researchers
- Principal investigator: Parent, Matthew T — Marine Biological Laboratory
- Study coordinator: Parent, Matthew T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.