Developing a new imaging system to analyze cancer organoids
3D Fourier Imaging System for High Throughput Analyses of Cancer Organoids
This study is working on a new imaging system to take detailed pictures of tiny 3D models of tumors, helping doctors understand how different tumors react to treatments like chemotherapy, so they can create better, personalized cancer therapies for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10793629 on NIH RePORTER |
What this research studies
This research focuses on creating an advanced imaging system that can analyze tumor organoids, which are 3D models of patient tumors. By integrating innovative imaging techniques, the project aims to capture detailed cellular structures and behaviors within these organoids, allowing for a better understanding of how tumors respond to treatments like chemotherapy. The approach involves using a method called Fourier ptychographic microscopy to achieve high-resolution images over a wide field of view, which is crucial for studying tumor heterogeneity and drug resistance. This could lead to more effective cancer treatments tailored to individual patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancer who are undergoing treatment and may benefit from personalized therapy approaches.
Not a fit: Patients with non-cancerous conditions or those who do not have access to tumor organoid technology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the ability to test and develop personalized cancer therapies.
How similar studies have performed: Other research has shown promise in using advanced imaging techniques for cancer studies, indicating that this approach could be effective.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Lee, Hakho — Massachusetts General Hospital
- Study coordinator: Lee, Hakho
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.