Developing a new imaging system for detailed 3D images of biological tissues
Official title: Ultra-stable, phase sensitive, snapshot OCT system enabled by 2-Photon additive manufacturing
Funded at University of Southern California · NIH-10929294 · Data updated 2026-11-12
This study is testing a new imaging system that uses 3D printing to create special mirrors, helping doctors take clear, detailed pictures of tissues in real-time, which could make it easier to spot and understand different medical conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $195,490 |
| NIH project number | 5R21GM149078-02 |
| Project ID | NIH-10929294 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients requiring detailed imaging of biological tissues, such as those with cardiovascular or dermatological conditions.
✕Less likely to help
Patients with conditions that do not require advanced imaging techniques or those who are not undergoing procedures that involve imaging may not benefit from this research.
What this research studies
This research focuses on creating a cutting-edge imaging system that uses advanced 3D printing technology to produce high-quality optical structures for volumetric imaging. By employing a technique called Full Field Spectral Domain Optical Coherence Tomography (FFSDOCT), the researchers aim to capture detailed images of biological tissues in real-time. The system will utilize a custom-designed 3D printed mirror with thousands of facets to enhance imaging capabilities without moving parts, allowing for rapid and precise imaging. This innovative approach could significantly improve the way we visualize and diagnose various medical conditions.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and faster imaging techniques for diagnosing and monitoring various medical conditions.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques, but this specific approach utilizing 3D printing for OCT imaging is relatively novel.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Applegate, Brian E. — University of Southern California
- Study coordinator: Applegate, Brian E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.