Developing a new drug delivery system for liver cancer treatment
Pre-IND Development of Polymeric Micelles with Dual Drug Payloads for HCC Therapy
This study is exploring a new way to deliver two cancer-fighting drugs directly to liver tumors in mice, with the goal of making treatments safer and more effective for people with liver cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11061626 on NIH RePORTER |
What this research studies
This research focuses on creating a specialized delivery system using polymeric micelles to transport two drugs, paclitaxel and cyclopamine, specifically for treating hepatocellular adenocarcinoma (HCC). The approach involves testing this delivery method in mouse models to evaluate its effectiveness and safety. The study aims to understand how different doses affect drug metabolism and toxicity, particularly looking at differences between male and female responses. By improving drug delivery, the research seeks to enhance treatment outcomes for patients with liver cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with hepatocellular adenocarcinoma who are seeking innovative treatment options.
Not a fit: Patients with other types of cancer or those not diagnosed with hepatocellular adenocarcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatment options for patients with liver cancer.
How similar studies have performed: Previous research has shown promise in using polymeric micelles for drug delivery in cancer treatment, indicating potential success for this approach.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Li, Chun — University of Tx Md Anderson Can Ctr
- Study coordinator: Li, Chun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.