Developing a new device to analyze proteins and their variations.
Official title: Combining Separation, Digestion, and Ionization on a Mass Spectrometry Cartridge to Enable Biomedical Research on Proteoforms
Funded at Indiana University Indianapolis · NIH-10934321 · Data updated 2026-11-12
This study is working on a handy device that makes it easier for researchers to analyze proteins and their different forms, which can help us understand diseases better and find new ways to diagnose them, even if the researchers aren't experts in the field.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | September 25, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $325,013 |
| NIH project number | 5R01GM149786-02 |
| Project ID | NIH-10934321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve protein alterations, such as genetic disorders or diseases where biomarkers are crucial for diagnosis.
✕Less likely to help
Patients with conditions unrelated to protein alterations or those who do not require biomarker analysis may not benefit from this research.
What this research studies
This research focuses on creating a self-contained analytical device that simplifies the process of analyzing proteins and their various forms, known as proteoforms. These proteoforms can change due to genetic mutations or modifications and are important for understanding diseases and developing biomarkers. The device will automate the entire protein analysis workflow, making it easier for researchers, even those without specialized training in mass spectrometry, to participate in proteoform research. By integrating multiple functions into one cartridge, the research aims to enhance the efficiency and accessibility of protein analysis in biomedical studies.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and efficient methods for diagnosing diseases and understanding biological processes through protein analysis.
How similar studies have gone: Previous research has shown promise in developing similar analytical devices for protein analysis, indicating a potential for success in this novel approach.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Manicke, Nicholas E — Indiana University Indianapolis
- Study coordinator: Manicke, Nicholas E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.