Developing a new antidote for carbon monoxide poisoning and a biosensor for detection in cells
Official title: Optimization of a carbon monoxide (CO) sensing hemoprotein for applications as an antidote for CO poisoning and a biosensor for CO detection in living cells
Funded at Wayne State University · NIH-11126991 · Data updated 2026-11-12
This study is working on a new treatment for carbon monoxide poisoning that uses a special protein to help people recover faster and safer, while also creating a tool to measure carbon monoxide levels in cells to improve care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $248,827 |
| NIH project number | 4R00HL168224-03 |
| Project ID | NIH-11126991 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced carbon monoxide exposure or poisoning.
✕Less likely to help
Patients who have not been exposed to carbon monoxide or those with conditions unrelated to CO poisoning may not benefit from this research.
What this research studies
This research focuses on creating a novel antidote for carbon monoxide (CO) poisoning, which is a significant health risk in the U.S. The team is utilizing a specialized hemoprotein that has a strong affinity for CO, aiming to develop a treatment that can be administered intravenously. By identifying key components of this hemoprotein, the researchers hope to enhance its effectiveness and safety for patients suffering from CO exposure. Additionally, the research includes the development of a biosensor that can detect CO levels in living cells, potentially improving monitoring and treatment strategies.
Why it matters
Potential benefit: If successful, this research could provide a life-saving antidote for CO poisoning and improve detection methods for CO in medical settings.
How similar studies have gone: While the approach of using hemoproteins for CO detection is innovative, similar strategies have shown promise in other areas of biosensor development.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Dent, Matthew Ryan — Wayne State University
- Study coordinator: Dent, Matthew Ryan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.