Developing a new antibiotic to treat drug-resistant gonorrhea
Official title: A Novel Mechanism of Action Natural Product for Treatment of Drug-Resistant Gonorrhea
Funded at Cfd Research Corporation · NIH-11076691 · Data updated 2026-11-12
This study is working on a new antibiotic to help fight gonorrhea, especially the tough strains that don't respond to current treatments, using a special natural product that has shown promise in the lab.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cfd Research Corporation NIH-funded |
| Lab location | 1 site (Huntsville, United States) |
| Project start | April 18, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $289,050 |
| NIH project number | 5R43AI174490-02 |
| Project ID | NIH-11076691 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with gonorrhea, particularly those with infections resistant to current antibiotic treatments.
✕Less likely to help
Patients with non-gonococcal infections or those who do not have drug-resistant gonorrhea may not benefit from this research.
What this research studies
This research focuses on creating a new class of antibiotics specifically targeting Neisseria gonorrhoeae, the bacteria responsible for gonorrhea, which has become increasingly resistant to existing treatments. The project will utilize a novel natural product that has shown potent activity against this bacteria. Researchers will optimize this natural product to enhance its effectiveness and safety, followed by testing its efficacy in a mouse model of gonorrhea infection. The ultimate goal is to develop a new antibiotic that can effectively combat drug-resistant strains of gonorrhea.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment option for patients suffering from drug-resistant gonorrhea.
How similar studies have gone: While antibiotic resistance is a significant challenge, this approach utilizing a novel natural product is relatively new and has not been extensively tested in similar contexts.
Where this research is happening
-
Cfd Research Corporation
Huntsville, United States Active
Researchers
- Principal investigator: Singhal, Aj — Cfd Research Corporation
- Study coordinator: Singhal, Aj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.