Developing a new animal model for a neurological autoimmune disorder
An animal model of anti-AQP4 autoimmunity
['FUNDING_R21'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-11095984
This study is creating special mice that mimic a serious condition called neuromyelitis optica spectrum disorder, so researchers can test new treatments that might help calm the immune system and protect against damage caused by the disease.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-11095984 on ClinicalTrials.gov |
What this research studies
This research focuses on creating an animal model that mimics the autoimmune response seen in neuromyelitis optica spectrum disorder (AQP4 NMOSD), a serious neurological condition. By using genetically modified mice, the researchers aim to replicate the disease's pathology and immune response, which will allow for better testing of potential therapies that target the underlying cause of the disease. The study will explore methods to restore the aquaporin-4 protein in these mice to understand how this might affect the autoimmune response. This model will be crucial for preclinical testing of new treatments aimed at tolerizing the immune system to prevent damage caused by AQP4 autoimmunity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neuromyelitis optica spectrum disorder or those with related autoimmune neurological conditions.
Not a fit: Patients with other forms of autoimmune disorders that do not involve aquaporin-4 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from AQP4 NMOSD, potentially reducing disability and improving quality of life.
How similar studies have performed: While there have been advancements in understanding AQP4 NMOSD, the development of a specific animal model for this condition is relatively novel and has not been extensively tested in prior research.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OH, UNSONG — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: OH, UNSONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.