Developing a new adhesive to prevent pelvic organ prolapse in women
Official title: Bioactive adhesive material for early vaginal wall detachment in pelvic organ prolapse
Funded at University of Texas Arlington · NIH-10559652 · Data updated 2026-11-12
This study is working on a new, eco-friendly glue that can help women with early signs of vaginal wall detachment, which can lead to pelvic organ prolapse, by safely reattaching the vaginal wall to the pelvic muscles, aiming to prevent the need for surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Arlington NIH-funded |
| Lab location | 1 site (Arlington, United States) |
| Project start | February 1, 2019 |
| Project end | January 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $315,511 |
| NIH project number | 5R01HD097330-05 |
| Project ID | NIH-10559652 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women experiencing early vaginal wall detachment, particularly those who are aging.
✕Less likely to help
Patients who have already undergone corrective surgery for pelvic organ prolapse may not benefit from this research.
What this research studies
This research focuses on creating a biodegradable adhesive material that can help reattach the vaginal wall to the pelvic muscle in women experiencing early vaginal wall detachment, which can lead to pelvic organ prolapse (POP). The project aims to improve the strength and durability of a mussel-inspired adhesive to effectively prevent the progression of POP, a condition that affects a significant number of aging women. By addressing this issue early, the research seeks to reduce the need for corrective surgeries and associated complications. The methodology involves developing and testing this innovative adhesive in a controlled environment to ensure its effectiveness and safety.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of pelvic organ prolapse and the need for invasive surgeries in women.
How similar studies have gone: Previous research has shown promise in using biodegradable adhesives for similar applications, indicating potential success for this novel approach.
Where this research is happening
-
University of Texas Arlington
Arlington, United States Active
Researchers
- Principal investigator: Hong, Yi — University of Texas Arlington
- Study coordinator: Hong, Yi
Related research
Other NIH-funded projects on the same topics.
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Matrix Regenerative Nanotech to Slow Pelvic Organ Prolapse in Adults
A new nanoparticle-based treatment aims to slow pelvic organ prolapse in adults by reconnecting and strengthening elastic tissue to improve quality of life.
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Identifying early warning signs of pelvic organ prolapse in young women
This NIH grant aims to find early markers that signal risk of pelvic organ prolapse so we can prevent severe disease.
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New non-surgical option for treating pelvic organ prolapse
This study is testing a new, easy-to-use pessary for women over 50 with pelvic organ prolapse, designed to be more comfortable and simpler to insert and remove on their own.
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Creating a new type of graft to repair pelvic organ prolapse
This study is working on a new type of graft to help fix pelvic organ prolapse, aiming to create a safe and effective solution that mimics healthy vaginal tissue, so patients can have better outcomes and fewer complications.
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Improving Uroflowmetry: Do Pre-Procedure Reminders Help Women Undergoing Urodynamics
This study tests whether sending reminder calls before a urodynamics test helps women with pelvic floor disorders feel more prepared and less anxious, and whether it makes the procedure go more smoothly.
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Vaginal Vault Support at Hysterectomy
This trial tests a new double-ligament vault suspension during hysterectomy to help prevent vaginal apex prolapse in women undergoing the procedure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.