Developing a mouse model to understand Lyme neuroborreliosis
Official title: A murine model of Lyme neuroborreliosis
Funded at Michigan State University · NIH-10786495 · Data updated 2026-11-12
This study is working on creating a special type of mouse that can help us better understand how Lyme disease affects the nervous system, so we can learn more about the symptoms and inflammation it causes.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $187,734 |
| NIH project number | 1R21AI180412-01 |
| Project ID | NIH-10786495 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been diagnosed with Lyme disease and are experiencing neurological symptoms.
✕Less likely to help
Patients who have not been diagnosed with Lyme disease or do not exhibit neurological symptoms may not benefit from this research.
What this research studies
This research aims to create a new mouse model that can effectively mimic the neurological aspects of Lyme disease, specifically Lyme neuroborreliosis. By allowing the bacteria responsible for Lyme disease to enter the central and peripheral nervous systems, the researchers hope to observe the resulting inflammatory lesions and neurological symptoms. This model will help bridge the knowledge gap in understanding how Lyme disease affects the nervous system, which is currently limited due to the inadequacy of existing animal models. The study will utilize a specific mouse strain known as the Collaborative Cross to achieve these objectives.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from Lyme neuroborreliosis.
How similar studies have gone: While there have been studies on Lyme disease, the development of a suitable mouse model for Lyme neuroborreliosis is a novel approach that has not been extensively tested.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Rogovsky, Artem S — Michigan State University
- Study coordinator: Rogovsky, Artem S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.