Developing a mouse model to improve vocal learning for communication disorders
Neuroengineering a Robust Vocal Learning Phenotype in Mice as a Model for Treating Communication Disorders
['FUNDING_R01'] · ROCKEFELLER UNIVERSITY · NIH-10685974
This study is working on creating special mice that can learn to make different sounds, which could help us understand and improve treatments for people with communication disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ROCKEFELLER UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10685974 on ClinicalTrials.gov |
What this research studies
This research aims to create a mouse model that can enhance vocal learning, which may help in understanding and treating human communication disorders. By genetically engineering mice to exhibit vocal learning traits, researchers will investigate the brain circuits involved in speech and how they can be repaired or enhanced. The study focuses on the neural mechanisms that allow for vocal modifications and the sequencing of sounds, which are crucial for effective communication. This innovative approach could provide insights into the genetic and neurophysiological underpinnings of speech impairments.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research would be individuals with speech and language impairments, including those with conditions like apraxia or dyspraxia.
Not a fit: Patients who do not have communication disorders or those whose conditions are not related to vocal learning may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for individuals with communication disorders, improving their ability to speak and interact.
How similar studies have performed: While this approach is innovative, there have been successful studies in other species, such as songbirds, that have shown the potential for vocal learning interventions.
Where this research is happening
NEW YORK, UNITED STATES
- ROCKEFELLER UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JARVIS, ERICH D — ROCKEFELLER UNIVERSITY
- Study coordinator: JARVIS, ERICH D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.