Developing a method to preserve and improve living heart valves for children
Official title: Engineering a strategy for the preservation and rehabilitation of living allogenic heart valves
Funded at Columbia University Health Sciences · NIH-10998065 · Data updated 2026-11-12
This study is looking at a new way to keep heart valves for kids with heart problems healthy and ready to use, so they can grow and heal on their own, which could mean fewer surgeries as they get older.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 15, 2024 |
| Project end | September 14, 2027 |
| Funding year | 2024 |
| Award (this year) | $50,937 |
| NIH project number | 1F30HL174098-01A1 |
| Project ID | NIH-10998065 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pediatric patients under 11 years old who require heart valve replacement due to congenital heart defects.
✕Less likely to help
Patients who do not have congenital heart defects or are over the age of 11 may not benefit from this research.
What this research studies
This research focuses on creating a new way to preserve living allogenic heart valves, which are essential for pediatric patients with congenital heart defects. The goal is to enable these valves to grow and repair themselves, reducing the need for multiple surgeries as children grow. The researchers will investigate the factors that cause current heart valve replacements to fail and use this information to develop a better storage method that maintains the valves' viability and function for at least three weeks. This innovative approach aims to provide a more effective solution for heart valve replacement in young patients.
Why it matters
Potential benefit: If successful, this research could lead to heart valve replacements that grow with children, significantly reducing the number of surgeries they need.
How similar studies have gone: While living allogenic valve transplantation is a relatively new approach, similar strategies in tissue preservation have shown promise, indicating potential for success in this area.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Cordoves, Elizabeth Marie — Columbia University Health Sciences
- Study coordinator: Cordoves, Elizabeth Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.