Developing a male contraceptive by targeting a specific protein in sperm
Targeting Na,K-ATPase alpha4 for male contraception
This study is exploring a new, safe way for men to prevent pregnancy by blocking a specific protein that helps sperm move, which could lead to a reversible contraceptive option if it works well.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-10877993 on NIH RePORTER |
What this research studies
This research focuses on creating a safe and effective contraceptive method for men by targeting the Na,K-ATPase alpha4 protein, which is crucial for sperm function. The approach involves blocking this protein to prevent sperm motility and fertility, thereby providing a reversible contraceptive option. The research utilizes advanced biochemical techniques to understand how inhibiting this protein affects sperm parameters. If successful, this could lead to a new form of male contraception that is both effective and safe.
Who could benefit from this research
Good fit: Ideal candidates for this research would be healthy males who are seeking contraceptive options and are open to participating in clinical trials.
Not a fit: Patients who are not male or those who are not seeking contraception may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide men with a reliable and reversible contraceptive option, helping to reduce unintended pregnancies.
How similar studies have performed: While the approach of targeting specific proteins for male contraception is innovative, similar research has shown promise in animal models, indicating potential for success in human applications.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Blanco, V Gustavo — University of Kansas Medical Center
- Study coordinator: Blanco, V Gustavo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.