Developing a fast-acting antidote for methamphetamine overdose
Official title: Clinical Development of a Therapeutic Agent for Rapid Reversal of Methamphetamine Intoxication
Funded at Clear Scientific, LLC · NIH-10907555 · Data updated 2026-11-12
This study is testing a new treatment called CS-1103 that helps quickly remove methamphetamine from the body, making it safer for people who have overdosed on the drug, and it's aimed at helping emergency departments handle these situations better.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clear Scientific, LLC NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | August 15, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $4,092,920 |
| NIH project number | 5U01DA058548-02 |
| Project ID | NIH-10907555 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced acute methamphetamine intoxication and require emergency medical intervention.
✕Less likely to help
Patients who have not used methamphetamine or are not experiencing intoxication will not benefit from this research.
What this research studies
This research focuses on creating a new therapeutic agent, CS-1103, designed to rapidly reverse the effects of methamphetamine intoxication. The approach involves a small-molecule sequestrant that binds to methamphetamine in the bloodstream, facilitating its removal from the body through urine. The research aims to complete Phase 1b clinical trials to evaluate the safety and effectiveness of CS-1103 in humans, following promising results in animal studies. This could provide a critical solution for emergency departments dealing with methamphetamine overdoses.
Why it matters
Potential benefit: If successful, this research could provide a life-saving antidote for individuals experiencing methamphetamine intoxication.
How similar studies have gone: While the approach of using a sequestrant for drug reversal is novel, similar strategies have shown promise in other contexts, indicating potential for success.
Where this research is happening
-
Clear Scientific, LLC
Cambridge, United States Active
Researchers
- Principal investigator: Li, Xinhua — Clear Scientific, LLC
- Study coordinator: Li, Xinhua
Related research
Other NIH-funded projects on the same topics.
-
A rapid antidote for methamphetamine intoxication that can be given by IV
A phase 2a study tests CS-1103, a fast-acting treatment designed to reverse methamphetamine intoxication and help clear the drug from the body.
-
A new medicine to quickly reverse methamphetamine overdose
This project aims to develop a fast-acting medicine called CS-1103 to help people experiencing severe methamphetamine intoxication.
-
New antidote for overdoses involving fentanyl and xylazine
A new injectable medicine that quickly removes both fentanyl and xylazine to reverse sedation and breathing problems in people overdosing on these drugs.
-
A new treatment to quickly remove synthetic opioids from the body
This study is testing a new treatment called CS-1103 that helps quickly remove dangerous synthetic opioids like fentanyl from the body, aiming to provide a single dose that can restore normal breathing and keep people safe after an overdose.
-
Developing a new antidote for fentanyl and xylazine overdoses
This study is working on a new treatment to help people who have overdosed on a mix of fentanyl and xylazine, which regular naloxone can't fix, so that they can breathe better and feel more alert again.
-
New treatment to reverse opioid overdose
This study is testing a new injection called CS-1103 that aims to quickly reverse the effects of fentanyl overdoses, offering a potentially better option than the usual treatment, naloxone, for people who might need help in an emergency.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.