Developing a device to predict bleeding risks in heart support patients
Official title: Multifunctional coagulation and platelet profiling during cardiaccirculatory support
Funded at Coalesenz INC. · NIH-10922390 · Data updated 2026-11-12
This study is testing a new, easy-to-use device called iCoagLAB that helps quickly check bleeding risks for patients with serious heart problems who are using special heart support machines, making it safer for them during treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Coalesenz INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $295,915 |
| NIH project number | 1R41HL170886-01A1 |
| Project ID | NIH-10922390 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with advanced heart failure or severe cardiac dysfunction who are receiving mechanical circulatory support.
✕Less likely to help
Patients who are not undergoing mechanical circulatory support or do not have coagulation disorders may not benefit from this research.
What this research studies
This research focuses on creating a compact device called iCoagLAB that can quickly assess bleeding risks in patients receiving mechanical circulatory support (MCS) for serious heart conditions. MCS is used for patients with advanced heart failure or severe cardiac dysfunction, but it can lead to life-threatening bleeding in a significant number of cases. The iCoagLAB device aims to provide rapid and accurate coagulation testing at the point-of-care, allowing for timely interventions to manage bleeding risks effectively. By improving the monitoring of coagulation status, this research seeks to enhance patient safety during critical cardiac procedures.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of life-threatening bleeding in patients undergoing mechanical circulatory support.
How similar studies have gone: Other research has shown promise in developing point-of-care coagulation testing devices, indicating that this approach has potential for success.
Where this research is happening
-
Coalesenz INC.
Cambridge, United States Active
Researchers
- Principal investigator: Nadkarni, Seemantini K — Coalesenz INC.
- Study coordinator: Nadkarni, Seemantini K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.