Developing a blood test to track ALS progression and treatment response
Blood-based Biomarker for Characterizing Progression and Therapeutic Response in Amyotrophic Lateral Sclerosis
This study is looking at a new blood test that measures a marker called TDP43 to help track how ALS and related conditions like Alzheimer's are progressing, with the goal of improving care and treatment for patients.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Neurodex INC NIH-funded |
| Lab location | 1 site (Arlington, United States) |
| Project ID | NIH-11005933 on NIH RePORTER |
What this research studies
This research focuses on creating a blood-based biomarker called TDP43, which could help in understanding the progression of amyotrophic lateral sclerosis (ALS) and related dementias like Alzheimer's disease. The approach involves isolating neuron-derived extracellular vesicles from blood samples to measure TDP43 levels, which may indicate disease progression and response to therapies. By improving the accuracy of ALS diagnostics and treatment monitoring, this research aims to enhance patient care and clinical trial efficiency.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with amyotrophic lateral sclerosis (ALS) or related dementias.
Not a fit: Patients with conditions unrelated to ALS or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnostics and better treatment monitoring for patients with ALS and related dementias.
How similar studies have performed: Previous research has shown promise in using blood-based biomarkers for neurological conditions, indicating potential success for this novel approach.
Where this research is happening
Arlington, United States
- Neurodex INC — Arlington, United States (Active)
Researchers
- Principal investigator: Eitan, Erez — Neurodex INC
- Study coordinator: Eitan, Erez
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.