Determining safe drug dosing for critically ill children on life support
Physiologically-Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support
This study is looking at how to give the right amount of medicine to critically ill children who are on a special life support system, so they can get better safely and effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10576321 on NIH RePORTER |
What this research studies
This research investigates how to determine the appropriate dosing of medications for critically ill children receiving extracorporeal life support (ECLS). It uses advanced mathematical models to understand how ECLS affects drug behavior in the body, which is crucial since traditional dosing methods are not effective for this unique population. By translating laboratory findings into practical dosing guidelines, the research aims to improve the safety and effectiveness of drug treatments for these vulnerable patients. The goal is to ensure that children on ECLS receive the right amount of medication to avoid therapeutic failures and improve their chances of recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill children aged 0-21 years who are receiving extracorporeal life support.
Not a fit: Patients who are not critically ill or who are not receiving extracorporeal life support may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective medication dosing for critically ill children on life support.
How similar studies have performed: Other research has shown promise in using physiologically-based pharmacokinetic models for drug dosing, indicating potential success for this approach.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Watt, Kevin M — University of Utah
- Study coordinator: Watt, Kevin M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.