Detecting tuberculosis DNA in blood for better diagnosis
Official title: Multiplexed detection of cell-free M. Tuberculosis DNA and its drug-resistant variants in blood
Funded at Tulane University of Louisiana · NIH-10906099 · Data updated 2026-11-12
This study is testing a new way to find tuberculosis (TB) in blood samples using a special technique that looks for tiny pieces of the bacteria's DNA, which could help people with weakened immune systems or other types of TB get diagnosed more accurately and quickly.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | August 11, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $726,852 |
| NIH project number | 5R01AI175618-02 |
| Project ID | NIH-10906099 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suspected of having active tuberculosis, particularly those with compromised immune systems or extrapulmonary TB.
✕Less likely to help
Patients who have already been diagnosed with TB and are receiving effective treatment may not benefit directly from this research.
What this research studies
This research focuses on improving the diagnosis of tuberculosis (TB) by detecting cell-free DNA from the bacteria in blood samples. Current methods often struggle to accurately identify TB, especially in patients with weakened immune systems or extrapulmonary TB. By utilizing a novel CRISPR-Cas12a-based detection system, the study aims to enhance the sensitivity of TB detection, allowing for real-time monitoring of active infections and treatment responses. This approach could provide a more reliable and accessible means of diagnosing TB compared to traditional methods.
Why it matters
Potential benefit: If successful, this research could lead to faster and more accurate TB diagnoses, ultimately improving patient outcomes and treatment efficacy.
How similar studies have gone: Other research has shown promising results using CRISPR-based detection methods for various pathogens, indicating potential success for this novel approach in TB diagnosis.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Hu, Tony Y. — Tulane University of Louisiana
- Study coordinator: Hu, Tony Y.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.