Detecting small molecules in cells using metal-based sensors
Organometallic Sensors for Cellular Small Molecule Detection
This study is working on new sensors that can help detect tiny molecules in the body, like ethylene, which can indicate stress and may be linked to diseases such as cancer and heart problems, with the goal of improving how we monitor and understand these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Denver (Colorado Seminary) NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-10886037 on NIH RePORTER |
What this research studies
This research focuses on developing innovative sensors that utilize transition metal catalysts to detect small biologically relevant molecules, particularly ethylene, which is produced in the body during oxidative stress. The approach involves creating fluorescent probes that can identify these molecules in biological systems, potentially leading to better understanding and monitoring of various diseases. By adapting known catalysts for use in living organisms, the research aims to improve detection methods for biomarkers associated with conditions like cancer and cardiovascular diseases. Patients may benefit from advancements in diagnostic techniques that arise from this work.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to oxidative stress, such as cancer, cardiovascular diseases, or neurodegenerative disorders.
Not a fit: Patients without conditions related to oxidative stress or those not producing the relevant biomarkers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools for detecting diseases associated with oxidative stress.
How similar studies have performed: Previous research has shown promise in using metal-based sensors for biological detection, indicating potential success for this novel approach.
Where this research is happening
Denver, United States
- University of Denver (Colorado Seminary) — Denver, United States (Active)
Researchers
- Principal investigator: Michel, Brian — University of Denver (Colorado Seminary)
- Study coordinator: Michel, Brian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.