Detecting RNA variations and modifications using a new technology
High-throughput detection of transcriptomic and epitranscriptomic variation and kinetics using MarathonRT
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10864962
This study is exploring a new way to read long RNA strands to better understand how changes in RNA affect gene activity, which could help patients by improving our knowledge of their conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10864962 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new method for accurately sequencing long RNA transcripts, which helps in understanding how RNA modifications and alternative splicing affect gene expression. By using a specialized enzyme called MarathonRT, the researchers aim to identify specific RNA modifications and their positions without needing a reference genome. This technology is particularly important for studying how RNA changes over time in different cells and tissues, which can provide insights into various biological processes and diseases. Patients may benefit from advancements in understanding RNA behavior related to their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve significant RNA processing changes, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to RNA modifications or those not requiring RNA analysis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies by enhancing our understanding of RNA modifications in diseases.
How similar studies have performed: Other research has shown promise in using advanced sequencing technologies to analyze RNA, indicating that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PYLE, ANNA MARIE — YALE UNIVERSITY
- Study coordinator: PYLE, ANNA MARIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.