Detecting protein markers for early diagnosis of sepsis
Solid-state nanopore detection of protein biomarkers for early sepsisdiagnosis
['FUNDING_R01'] · UNIVERSITY OF MISSOURI-COLUMBIA · NIH-10914941
This study is working on a new, easy-to-use tool that can quickly find specific proteins in your blood that signal sepsis, helping doctors make faster and better treatment decisions for patients showing early signs of infection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MISSOURI-COLUMBIA (nih funded) |
| Locations | 1 site (COLUMBIA, UNITED STATES) |
| Trial ID | NIH-10914941 on ClinicalTrials.gov |
What this research studies
This research aims to develop a highly sensitive and portable sensing platform that can detect multiple protein biomarkers associated with sepsis in clinical samples. By utilizing advanced techniques such as magnetic beads and DNA-functionalized nanoparticles, the study seeks to improve the accuracy and speed of sepsis diagnosis, which is crucial given the condition's high mortality rate. Patients presenting with early signs of infection may benefit from this innovative approach, as it could lead to quicker and more effective treatment decisions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who are showing early signs of infection and are at risk for developing sepsis.
Not a fit: Patients who are not exhibiting any symptoms of infection or those with confirmed sepsis may not benefit from this specific diagnostic approach.
Why it matters
Potential benefit: If successful, this research could significantly reduce the time to diagnose sepsis, potentially saving lives and improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using nanopore technology for biomarker detection, indicating that this approach could be effective.
Where this research is happening
COLUMBIA, UNITED STATES
- UNIVERSITY OF MISSOURI-COLUMBIA — COLUMBIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUAN, XIYUN — UNIVERSITY OF MISSOURI-COLUMBIA
- Study coordinator: GUAN, XIYUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.