Detecting ovarian cancer through blood T-cell changes
Tracking Peripheral T-Cell Repertoire Changes for Preoperative and Early Ovarian Cancer Diagnosis
This study is looking at how changes in certain immune cells in your blood can help doctors find ovarian cancer earlier and more accurately, which could lead to better treatment options and less need for surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11025892 on NIH RePORTER |
What this research studies
This research aims to improve the early diagnosis of ovarian cancer by analyzing changes in the T-cell repertoire in the blood. Current methods for detecting ovarian cancer are often inaccurate, leading to late-stage diagnoses and unnecessary surgeries. By focusing on the immune response, specifically the presence of cancer-associated T cells, this study seeks to develop a more reliable preoperative diagnostic method. This innovative approach could help identify ovarian cancer at an earlier stage, significantly improving survival rates and reducing the need for invasive procedures.
Who could benefit from this research
Good fit: Ideal candidates for this research include women with adnexal masses or those at high risk for ovarian cancer.
Not a fit: Patients with confirmed ovarian cancer or those who do not have any adnexal masses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more accurate and less invasive method for diagnosing ovarian cancer, ultimately improving patient outcomes.
How similar studies have performed: While the approach of using T-cell repertoire changes for cancer detection is innovative, similar methodologies have shown promise in other cancers, indicating potential for success in this area.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Li, Bo — Children's Hosp of Philadelphia
- Study coordinator: Li, Bo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.