Detecting misfolded proteins in Alzheimer's disease using fluorescent probes
Official title: Fluorescent probes for detection of misfolded protein oligomers in Alzheimer's Disease and related disorders
Funded at University of South Florida · NIH-10788369 · Data updated 2026-11-12
This study is working on creating special dyes that can help spot the harmful protein clumps linked to Alzheimer's disease, which could lead to better ways to track how the disease progresses in patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | March 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $228,457 |
| NIH project number | 5R21AG077735-02 |
| Project ID | NIH-10788369 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related disorders who may provide tissue samples for analysis.
✕Less likely to help
Patients with other forms of dementia that do not involve amyloid beta oligomers may not benefit from this research.
What this research studies
This research focuses on developing fluorescent probes that can specifically detect misfolded protein oligomers associated with Alzheimer's disease. These oligomers are believed to play a critical role in the onset and progression of the disease, and the study aims to create dyes that can accurately identify them in biological samples. By validating these probes in animal models and patient tissues, the research seeks to improve our understanding of Alzheimer's pathology and potentially enhance diagnostic capabilities. Patients may benefit from more accurate monitoring of disease progression through these innovative detection methods.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools for early detection and monitoring of Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using similar fluorescent techniques for detecting protein aggregates, suggesting potential for success in this novel approach.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Muschol, Martin — University of South Florida
- Study coordinator: Muschol, Martin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.