Detecting lung problems in children after stem cell transplants using advanced MRI techniques.
Early detection of pulmonary complications of hematopoietic stem-cell transplantation in children using hyperpolarized xenon MRI
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11010031
This study is looking at a new way to spot lung problems early in kids who have had a stem cell transplant, using a special type of MRI that makes it easier for them, so they don’t have to do the usual lung tests; the aim is to catch any issues sooner to help keep their lungs healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11010031 on ClinicalTrials.gov |
What this research studies
This research focuses on improving the early detection of lung complications in children who have undergone hematopoietic stem-cell transplantation (HSCT). It utilizes a novel imaging technique called hyperpolarized xenon MRI, which allows for detailed visualization of lung function without requiring children to perform traditional lung tests like spirometry. By identifying lung issues earlier, the goal is to provide timely interventions that can prevent further damage and improve overall health outcomes for these young patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 18 years old who have undergone hematopoietic stem-cell transplantation and are unable to perform standard lung function tests.
Not a fit: Patients who are older than 18 years or those who have not undergone hematopoietic stem-cell transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better management of lung complications in children after stem cell transplants, potentially reducing morbidity and mortality.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques for lung diagnostics, but this specific approach with hyperpolarized xenon MRI in pediatric HSCT patients is relatively novel.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WALKUP, LAURA LEE — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: WALKUP, LAURA LEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.