Detecting lung cancer during surgery using special fluorescent markers
Translating phospholipase activatable fluorophores for the sensitive detection of non-small cell lung cancer
This study is testing a new way to help surgeons spot and remove non-small cell lung cancer more easily during surgery by using special glowing markers, which could lead to better results and fewer chances of the cancer coming back.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11094756 on NIH RePORTER |
What this research studies
This research focuses on improving the detection of non-small cell lung cancer (NSCLC) during surgical procedures by using activatable fluorescent markers that target a specific enzyme. These markers will enhance the visibility of tumors, allowing surgeons to identify and remove cancerous tissue more effectively. By utilizing near-infrared imaging, the study aims to provide real-time feedback during surgery, which could lead to better outcomes for patients by reducing the chances of cancer recurrence. The approach is designed to help ensure that all cancerous cells are removed, which is crucial for patient survival and quality of life.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with early-stage non-small cell lung cancer who are scheduled for surgical resection.
Not a fit: Patients with advanced-stage lung cancer or those who are not candidates for surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve surgical outcomes for lung cancer patients by reducing the rate of cancer recurrence.
How similar studies have performed: Previous research has shown promise in using similar fluorescent imaging techniques for cancer detection, indicating a potential for success in this novel application.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Delikatny, Edward J — University of Pennsylvania
- Study coordinator: Delikatny, Edward J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.