Detecting late brain changes after a traumatic brain injury
Clinical & biological signatures of post-traumatic neurodegeneration: Leveraging the TBI Model Systems of Care to accelerate in vivo diagnosis of the late effects of TBI (LETBI)
Finding clinical signs, brain imaging results, and blood or other biomarkers that help diagnose long-term brain problems in people who have had a traumatic brain injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10699877 on NIH RePORTER |
What this research studies
If you've had a traumatic brain injury (TBI), this work follows people through the TBI Model Systems of Care to collect clinical exams, brain imaging, and biological samples like blood to look for Alzheimer-related markers such as Aβ42. Researchers will combine your symptoms, test results, and computer algorithms to spot patterns that point to delayed neurodegeneration after TBI. The project uses active follow-up so changes over months or years can be tracked. Results are meant to improve how doctors recognize and describe the late effects of TBI while you continue regular care.
Who could benefit from this research
Good fit: People who previously experienced a moderate-to-severe TBI or who are enrolled at a TBI Model Systems center and are willing to attend follow-up visits and provide clinical information and biospecimens.
Not a fit: People without a history of TBI or whose memory problems are clearly due to other causes may not directly benefit from this project.
Why it matters
Potential benefit: If successful, this could help diagnose TBI-related neurodegeneration earlier and more accurately so people and their clinicians can plan care and interventions sooner.
How similar studies have performed: Prior studies have linked TBI to later Alzheimer-type changes and used biomarkers like Aβ42, but combining clinical signs, imaging, and biomarkers across the TBI Model Systems network for in vivo diagnosis is a newer and less-tested approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Dams-O'connor, Kristen — Icahn School of Medicine at Mount Sinai
- Study coordinator: Dams-O'connor, Kristen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.