Detecting HPV16 E6 antibodies to identify early signs of oropharyngeal cancer in men with HIV
Official title: HPV16 E6 Antibody Detection as an Early Marker for Oropharyngeal Cancer Among Men Living with HIV
Funded at University of Kentucky · NIH-10837005 · Data updated 2026-11-12
This study is looking at men with HIV to see if certain antibodies in their blood can help spot oropharyngeal cancer early, which could lead to better ways to catch this cancer sooner for those at higher risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | February 5, 2021 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $219,274 |
| NIH project number | 5R01DE029650-06 |
| Project ID | NIH-10837005 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men living with HIV, particularly those who may be at higher risk for developing HPV-related cancers.
✕Less likely to help
Patients who are not living with HIV or who do not have a risk of HPV-related cancers may not benefit from this research.
What this research studies
This research focuses on men living with HIV and aims to identify early markers for oropharyngeal cancer, specifically through the detection of HPV16 E6 antibodies. The study investigates how these antibodies can serve as a biomarker for early detection, potentially allowing for timely intervention. By analyzing blood samples from participants, researchers hope to establish a correlation between antibody presence and the risk of developing HPV-related cancers. This could lead to improved screening methods for those at higher risk.
Why it matters
Potential benefit: If successful, this research could enable earlier detection of oropharyngeal cancer in men living with HIV, leading to better treatment outcomes.
How similar studies have gone: Previous research has shown promise in using HPV16 E6 antibodies as biomarkers for early detection of HPV-related cancers, indicating a potential for success in this approach.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Kuhs, Krystle a. — University of Kentucky
- Study coordinator: Kuhs, Krystle a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.