Detecting how DNA pairs during cell division and genetic exchange
Official title: Assay for Detection of Homologous DNA Interactions
Funded at Cleveland State University · NIH-11059241 · Data updated 2026-11-12
This study is looking at how certain DNA segments work together in living cells, using yeast to help us understand how these interactions affect important processes like cell division and repair, which could lead to better insights for patients with conditions like cancer and genetic disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | May 1, 2022 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $477,322 |
| NIH project number | 5R01GM141698-04 |
| Project ID | NIH-11059241 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders, cancers, or those interested in the mechanisms of chromosome behavior and genetic exchange.
✕Less likely to help
Patients with conditions unrelated to DNA interactions or chromosome structure may not benefit from this research.
What this research studies
This research investigates the interactions between homologous DNA segments, which are crucial for maintaining chromosome structure and function. By developing a novel assay called the Homologous Pairing Capture (HPC), the team aims to identify and quantify these DNA interactions in living cells, specifically using budding yeast as a model. The study focuses on understanding how these interactions contribute to chromosome segregation, repair, and genetic diversity, which are essential processes in both normal development and disease. Patients may benefit from insights gained about the mechanisms underlying conditions like cancer and genetic disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for genetic disorders and cancers linked to DNA mispairing.
How similar studies have gone: Previous research has shown promise in understanding DNA interactions, but this specific approach using the HPC assay is relatively novel.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Boerner, Valentin — Cleveland State University
- Study coordinator: Boerner, Valentin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.