Detecting hidden cancers in the head and neck using advanced nanoprobes
A pH Responsive Transistor-like Nanoprobe for Sensitive Detection of Unknown Primary Cancers of the Head and Neck
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11110338
This study is testing a new tool that can help find tiny, hidden cancers in the head and neck area that regular scans might miss, making it easier for doctors to spot and treat them, which could lead to better health for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11110338 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a novel nanoprobe that can detect unknown primary cancers in the head and neck region, particularly those that are too small to be identified through traditional imaging methods. The nanoprobe is designed to respond to the acidic environment often found in tumors, changing its fluorescence to signal the presence of cancerous cells. By improving the sensitivity of detection, this approach aims to locate and remove these hidden tumors, which can significantly enhance patient outcomes. The research includes ongoing clinical trials to evaluate the effectiveness of this technology in real-world settings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with head and neck squamous cell carcinoma, particularly those with unknown primary cancers.
Not a fit: Patients with well-defined primary tumors that are easily detectable through conventional imaging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate detection of head and neck cancers, improving treatment options and survival rates for patients.
How similar studies have performed: Similar approaches using nanoprobe technology have shown promise in other cancer detection studies, indicating potential for success in this novel application.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUMER, BARAN D — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: SUMER, BARAN D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.