Detecting hidden brain diseases using artificial intelligence

Covert Cerebrovascular Disease Detected by Artificial Intelligence (C2D2AI): Pragmatic Neuroimaging Biomarkers for Future Stroke and Dementia Risk

NIH-funded research Tufts Medical Center · NIH-11035080

This study is looking to find hidden brain problems that can lead to strokes and memory issues by using advanced imaging and smart computer technology, so we can help people catch these risks early and stay healthier longer.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionTufts Medical Center NIH-funded
Lab location1 site (Boston, United States)
Project IDNIH-11035080 on NIH RePORTER

What this research studies

This research focuses on identifying covert cerebrovascular disease (CCD), which includes covert brain infarction and white matter disease, through advanced neuroimaging techniques and artificial intelligence. By analyzing routine clinical scans, the study aims to uncover these hidden conditions that are often missed but can significantly increase the risk of future strokes and dementia. The approach involves using AI algorithms to improve the detection and understanding of these diseases, ultimately helping to identify individuals at high risk before they experience severe cognitive decline.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals who have undergone neuroimaging scans and may have undetected covert cerebrovascular disease.

Not a fit: Patients who do not have access to neuroimaging or those without risk factors for cerebrovascular disease may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to earlier detection and intervention for patients at risk of stroke and dementia, potentially improving their long-term health outcomes.

How similar studies have performed: Previous studies have shown promise in using AI for medical imaging, suggesting that this approach could be effective in detecting covert cerebrovascular diseases.

Where this research is happening

Boston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.