Detecting harmful compounds in the body using advanced sensors
Official title: Selenium-based electrocatalytic sensors for sensitive peroxynitrite detection in biological media: a bottom-up approach for functional interface design
Funded at Cleveland State University · NIH-10799038 · Data updated 2026-11-12
This study is working on new sensors that can detect a harmful substance called peroxynitrite, which is linked to heart problems and inflammation, to help researchers better understand its impact on health.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $100,000 |
| NIH project number | 3R15GM140405-01A1S1 |
| Project ID | NIH-10799038 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may be affected by conditions related to oxidative stress, such as cardiovascular diseases or chronic inflammation.
✕Less likely to help
Patients who do not have conditions associated with peroxynitrite or oxidative stress may not benefit from this research.
What this research studies
This research focuses on developing innovative sensors that can accurately detect peroxynitrite, a harmful compound linked to various health issues like cardiovascular diseases and inflammation. By utilizing a bottom-up approach to design biocompatible materials, the project aims to create electrochemical sensors that can operate effectively in biological environments. These sensors will help in monitoring peroxynitrite levels, which is crucial for understanding its role in disease processes and cellular damage. The methodology involves creating sensitive interfaces that can respond to low concentrations of peroxynitrite, making it easier to study its effects on human health.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools for detecting and monitoring conditions related to peroxynitrite, potentially improving patient outcomes.
How similar studies have gone: While the detection of peroxynitrite is a challenging area, similar electrochemical detection methods have shown promise in other studies, indicating potential for success in this novel approach.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Bayachou, Mekki — Cleveland State University
- Study coordinator: Bayachou, Mekki
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.