Detecting harmful compounds in the body using advanced sensors
Official title: Selenide-based electrocatalytic sensors for sensitive peroxynitrite detection in biological media: a bottom-up approach for functional interface design
Funded at Cleveland State University · NIH-10203223 · Data updated 2026-11-12
This study is working on creating special sensors that can detect a harmful substance called peroxynitrite, which is connected to heart problems and inflammation, to help improve how we diagnose and understand these health issues.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2021 |
| Award (this year) | $447,128 |
| NIH project number | 1R15GM140405-01A1 |
| Project ID | NIH-10203223 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who may be affected by cardiovascular diseases or chronic inflammatory conditions.
✕Less likely to help
Patients with conditions unrelated to peroxynitrite or those under 21 years old may not benefit from this research.
What this research studies
This research focuses on developing sensitive sensors to detect peroxynitrite, a harmful compound linked to various health issues such as cardiovascular diseases and inflammation. By utilizing a bottom-up approach for designing functional interfaces, the project aims to create effective tools for measuring peroxynitrite levels in biological samples. This could help in understanding its role in disease processes and potentially lead to better diagnostic methods. The research involves innovative techniques in pharmaceutical chemistry and cellular physiology.
Why it matters
Potential benefit: If successful, this research could lead to improved detection methods for peroxynitrite, enhancing diagnosis and treatment of related health conditions.
How similar studies have gone: While the detection of peroxynitrite is a critical area of study, this specific approach using selenide-based sensors is relatively novel and has not been extensively tested in prior research.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Bayachou, Mekki — Cleveland State University
- Study coordinator: Bayachou, Mekki
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.