Detecting early signs of vascular problems using advanced imaging techniques
Early Detection of Vascular Dysfunction Using Biomarkers from Lagrangian Carotid Strain Imaging
This study is looking at a new way to check how healthy your carotid artery is by seeing how it moves with blood flow, which could help spot early signs of problems like atherosclerosis and identify risky plaques that might cause strokes, and it's open to both healthy volunteers and patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10653121 on NIH RePORTER |
What this research studies
This research investigates a new method called Lagrangian carotid strain imaging to detect early signs of vascular dysfunction related to atherosclerosis. By measuring how the carotid artery tissue moves during blood flow, researchers aim to identify vulnerable plaques that could lead to serious complications like strokes. The study will involve both asymptomatic volunteers and patients, focusing on the mechanical properties of plaques to better understand their risk of rupture. This innovative approach could provide valuable biomarkers for assessing vascular health and aging.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for atherosclerosis, particularly those with a family history of cardiovascular disease or other risk factors.
Not a fit: Patients with established severe atherosclerotic disease or those already experiencing significant cardiovascular events may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of vascular issues, potentially preventing strokes and improving patient outcomes.
How similar studies have performed: Other research has shown promise in using advanced imaging techniques to assess vascular health, suggesting that this approach could be effective.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Varghese, Tomy — University of Wisconsin-Madison
- Study coordinator: Varghese, Tomy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.