Detecting early signs of relapse in blood cancer after stem cell transplants
Understanding Transplant Relapse of the Myelodysplastic Syndromes through Early Detection of Residual Disease among Hematopoietic Stem Cells
This study is looking at how myelodysplastic syndromes (MDS) can come back after treatment, especially after stem cell transplants, by checking for specific blood cells that might show if the disease is still there, which could help improve how we keep an eye on and treat patients with MDS.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11071722 on NIH RePORTER |
What this research studies
This research focuses on understanding how myelodysplastic syndromes (MDS), a type of blood cancer, can relapse after treatment, particularly after stem cell transplants. The study aims to identify and analyze hematopoietic stem cells (HSCs) that may indicate the presence of residual disease. By using advanced sequencing techniques, researchers will examine these rare cells to see if they can predict relapse in patients. This could lead to better monitoring and treatment strategies for those affected by MDS.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with myelodysplastic syndromes who have undergone or are planning to undergo allogeneic stem cell transplantation.
Not a fit: Patients with other types of blood cancers or those who have not received stem cell transplants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection of relapse in patients with myelodysplastic syndromes, potentially enhancing treatment outcomes.
How similar studies have performed: Previous research has shown promise in using targeted sequencing to detect mutations in blood cancers, suggesting that this approach may yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Kroger, Benjamin — Ut Southwestern Medical Center
- Study coordinator: Kroger, Benjamin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.