Detecting early signs of relapse in blood cancer after stem cell transplants
Official title: Understanding Transplant Relapse of the Myelodysplastic Syndromes through Early Detection of Residual Disease among Hematopoietic Stem Cells
Funded at Ut Southwestern Medical Center · NIH-11071722 · Data updated 2026-11-12
This study is looking at how myelodysplastic syndromes (MDS) can come back after treatment, especially after stem cell transplants, by checking for specific blood cells that might show if the disease is still there, which could help improve how we keep an eye on and treat patients with MDS.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | January 28, 2025 |
| Project end | January 27, 2028 |
| Funding year | 2025 |
| Award (this year) | $42,959 |
| NIH project number | 1F30HL178281-01 |
| Project ID | NIH-11071722 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with myelodysplastic syndromes who have undergone or are planning to undergo allogeneic stem cell transplantation.
✕Less likely to help
Patients with other types of blood cancers or those who have not received stem cell transplants may not benefit from this research.
What this research studies
This research focuses on understanding how myelodysplastic syndromes (MDS), a type of blood cancer, can relapse after treatment, particularly after stem cell transplants. The study aims to identify and analyze hematopoietic stem cells (HSCs) that may indicate the presence of residual disease. By using advanced sequencing techniques, researchers will examine these rare cells to see if they can predict relapse in patients. This could lead to better monitoring and treatment strategies for those affected by MDS.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection of relapse in patients with myelodysplastic syndromes, potentially enhancing treatment outcomes.
How similar studies have gone: Previous research has shown promise in using targeted sequencing to detect mutations in blood cancers, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Kroger, Benjamin — Ut Southwestern Medical Center
- Study coordinator: Kroger, Benjamin
Related research
Other NIH-funded projects on the same topics.
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Understanding why some MDS patients relapse after a stem cell transplant
A study of patients with myelodysplastic syndromes after stem cell transplant to learn the cellular changes and gene activity that lead to relapse, with the goal of guiding future treatments.
-
Targeting early oral GVHD to improve mouth health after stem cell transplant
A study at UW–Madison will explore why some transplant patients develop painful oral GVHD and test ideas to prevent and lessen mouth-related problems.
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Innate and Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury
A liver transplant-focused project investigates how the body’s early and later immune responses affect transplant failure or success after reperfusion.
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A tailored exercise and lifestyle program is being tested to reduce frailty and improve outcomes for people waiting for a lung transplant.
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Social stress and smoking: why disadvantaged young adults struggle to quit
This grant looks at how daily social stress affects if and when disadvantaged young adults who smoke can quit and stay quit.
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Diabetes and Donor Tissue in Corneal Transplants
This grant studies whether corneas from donors with diabetes affect the success of Descemet membrane endothelial keratoplasty (DMEK) and what factors predict better or worse outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.