Detecting early signs of HPV-related throat cancer using a biomarker approach

Who could benefit from this research

What this research studies

This research focuses on developing a non-invasive oral gargle test to detect early signs of oropharyngeal cancer (OPC) caused by HPV. The approach involves analyzing a panel of biomarkers from a single oral gargle specimen, which can differentiate between early-stage OPC and healthy controls. By utilizing existing biorepositories and advanced genomic techniques, the study aims to improve the accuracy of early detection, potentially leading to better treatment outcomes for patients. The research is designed to validate this biomarker panel for clinical use, making it easier for patients to undergo screening.

Why it matters

Where this research is happening

• H. Lee Moffitt Cancer Ctr & Res Inst
  Tampa, United States Active

Researchers

• Principal investigator: Giuliano, Anna R. — H. Lee Moffitt Cancer Ctr & Res Inst
• Study coordinator: Giuliano, Anna R.

Related research

Other NIH-funded projects on the same topics.

• AI-powered predictor for chemoradiation response in Veterans with oropharyngeal cancer

  A new AI-based tool will help doctors tailor chemoradiation for Veterans with oropharyngeal cancer by predicting how each patient will respond to treatment.

  NIH research Michael E Debakey VA Medical Center · Houston, United States · NIH-11474322

• OPC Survivor: Optimizing Long-Term Health After Oropharyngeal Cancer

  This program studies how to improve long-term health and quality of life for adults treated for HPV-related oropharyngeal cancer.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11415554

• Optimizing HPV-positive oropharyngeal cancer treatment by selecting patients and reducing therapy intensity

  This grant explores whether we can choose the right patients with HPV-positive throat cancer for less intensive, less toxic treatment while maintaining excellent outcomes.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11404947

• Biological factors behind different outcomes in HPV+ oropharyngeal cancer

  This project looks at why some people with HPV-positive throat cancer have better or worse survival, by studying tumor biology in a large Cleveland patient group.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11399180

• Understanding how oral high-risk HPV progresses in people with HIV to prevent oropharyngeal cancer

  This study follows HIV patients at high risk for HPV-related throat cancer to understand how oral HPV infections start and change over time, with the goal of catching precancer early.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11380555

• Biomarker-based screening to find HPV-related oropharyngeal cancer early

  A non-invasive oral gargle test is being developed to detect HPV-related oropharyngeal cancer at early stages, helping people at risk catch cancer sooner.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11365061

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.