Detecting early signs of HPV-related throat cancer using a biomarker approach
Biomarker Approach to Screening for the early detection of HPV-related Oropharyngeal Cancer (BASH OPC)
This study is testing a simple mouth rinse that could help find early signs of throat cancer caused by HPV, making it easier for people to get screened and potentially improving their treatment options.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10919871 on NIH RePORTER |
What this research studies
This research focuses on developing a non-invasive oral gargle test to detect early signs of oropharyngeal cancer (OPC) caused by HPV. The approach involves analyzing a panel of biomarkers from a single oral gargle specimen, which can differentiate between early-stage OPC and healthy controls. By utilizing existing biorepositories and advanced genomic techniques, the study aims to improve the accuracy of early detection, potentially leading to better treatment outcomes for patients. The research is designed to validate this biomarker panel for clinical use, making it easier for patients to undergo screening.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for HPV-related oropharyngeal cancer, particularly those with a history of HPV infection.
Not a fit: Patients who do not have HPV-related oropharyngeal cancer or those with advanced-stage cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of oropharyngeal cancer, significantly improving patient outcomes and reducing the need for intensive treatments.
How similar studies have performed: Previous studies have shown promise in using biomarker panels for cancer detection, indicating that this approach has potential for success.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Giuliano, Anna R. — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Giuliano, Anna R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.