Detecting drug-resistant Candida infections using advanced PCR techniques
Identifying drug-resistant Candida species using SuperSelective primer PCR
['FUNDING_R21'] · HACKENSACK UNIVERSITY MEDICAL CENTER · NIH-10745989
This study is working on a new test to quickly find drug-resistant strains of Candida auris, a tough fungus that can make people very sick, so that doctors can provide the right treatment faster for those who need it.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HACKENSACK UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (HACKENSACK, UNITED STATES) |
| Trial ID | NIH-10745989 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new diagnostic tool to identify drug-resistant strains of Candida auris, a serious fungal pathogen that poses a global health threat. The study aims to create SuperSelective PCR assays that can detect specific genetic mutations associated with antifungal resistance, even in the presence of a large amount of non-resistant DNA. By improving the sensitivity of detection, the research seeks to enable timely and effective treatment strategies for patients infected with this challenging organism.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have been diagnosed with Candida auris infections or are at high risk for such infections.
Not a fit: Patients with non-Candida auris fungal infections or those who do not have any fungal infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to faster and more accurate diagnoses of drug-resistant Candida infections, allowing for more effective treatment options.
How similar studies have performed: Previous research has shown promise in developing sensitive diagnostic assays for fungal infections, indicating that this approach could be effective.
Where this research is happening
HACKENSACK, UNITED STATES
- HACKENSACK UNIVERSITY MEDICAL CENTER — HACKENSACK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAUHAN, NEERAJ — HACKENSACK UNIVERSITY MEDICAL CENTER
- Study coordinator: CHAUHAN, NEERAJ
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.