Detecting chromosomal changes in cancer tissue samples
Chromosomal aberration detection in FFPE tissue using proximity ligation sequencing
['FUNDING_SBIR_2'] · PHASE GENOMICS, INC. · NIH-10934589
This study is testing a new way to find genetic changes in solid tumors using a special technique on tissue samples, which could help doctors make more accurate cancer diagnoses and choose better treatments for patients.
Quick facts
| Phase | ['FUNDING_SBIR_2'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PHASE GENOMICS, INC. (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10934589 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new method to detect chromosomal aberrations in solid tumors using a technique called proximity ligation sequencing. By analyzing formalin-fixed paraffin-embedded (FFPE) tissue samples, which are commonly used in cancer diagnostics, the researchers aim to identify various chromosomal abnormalities that can indicate the presence of cancer. The approach utilizes advanced genomic sequencing techniques to provide high-resolution insights into the genetic alterations present in tumors, potentially leading to better diagnostic tools. Patients may benefit from this research as it could improve the accuracy of cancer diagnoses and inform treatment decisions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with solid tumors whose biopsies are stored in FFPE tissue blocks.
Not a fit: Patients with blood neoplasms or those whose tumors cannot be analyzed using FFPE samples may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate cancer diagnoses and personalized treatment options for patients.
How similar studies have performed: Other research has shown promise in using proximity ligation techniques for genomic analysis, indicating potential success for this novel approach.
Where this research is happening
SEATTLE, UNITED STATES
- PHASE GENOMICS, INC. — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EACKER, STEPHEN MATTHEW — PHASE GENOMICS, INC.
- Study coordinator: EACKER, STEPHEN MATTHEW
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers