Detecting chromosomal changes in cancer tissue samples
Official title: Chromosomal aberration detection in FFPE tissue using proximity ligation sequencing
Funded at Phase Genomics, INC. · NIH-10934589 · Data updated 2026-11-12
This study is testing a new way to find genetic changes in solid tumors using a special technique on tissue samples, which could help doctors make more accurate cancer diagnoses and choose better treatments for patients.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Phase Genomics, INC. NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 25, 2023 |
| Project end | August 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,141,676 |
| NIH project number | 5R44CA281528-02 |
| Project ID | NIH-10934589 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with solid tumors whose biopsies are stored in FFPE tissue blocks.
✕Less likely to help
Patients with blood neoplasms or those whose tumors cannot be analyzed using FFPE samples may not benefit from this research.
What this research studies
This research focuses on developing a new method to detect chromosomal aberrations in solid tumors using a technique called proximity ligation sequencing. By analyzing formalin-fixed paraffin-embedded (FFPE) tissue samples, which are commonly used in cancer diagnostics, the researchers aim to identify various chromosomal abnormalities that can indicate the presence of cancer. The approach utilizes advanced genomic sequencing techniques to provide high-resolution insights into the genetic alterations present in tumors, potentially leading to better diagnostic tools. Patients may benefit from this research as it could improve the accuracy of cancer diagnoses and inform treatment decisions.
Why it matters
Potential benefit: If successful, this research could lead to more accurate cancer diagnoses and personalized treatment options for patients.
How similar studies have gone: Other research has shown promise in using proximity ligation techniques for genomic analysis, indicating potential success for this novel approach.
Where this research is happening
-
Phase Genomics, INC.
Seattle, United States Active
Researchers
- Principal investigator: Eacker, Stephen Matthew — Phase Genomics, INC.
- Study coordinator: Eacker, Stephen Matthew
Related research
Other NIH-funded projects on the same topics.
-
Using mRNA technology to deliver targeted antimicrobial treatments
This study is exploring a new way to fight tough bacterial infections, especially those that don't respond to regular antibiotics, by using a special technology that helps your body make proteins to target and eliminate harmful bacteria.
-
Using AI to improve risk assessment for acute myeloid leukemia
This study is looking at how certain hidden changes in chromosomes can help us better understand acute myeloid leukemia (AML) and improve predictions about how patients will do, especially for those who are considered at intermediate risk, so that doctors can tailor treatments more effectively.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.