Detecting brain membrane changes from repeated head impacts in athletes
MR elastography-based detection of impaired decoupling performance of the pia-arachnoid complex (PAC) associated with repetitive head impacts
This study is looking at how repeated head impacts from contact sports might affect a protective layer around the brain, and it aims to create a simple, noninvasive way to spot early signs of injury in athletes, helping to improve their care and safety.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10676760 on NIH RePORTER |
What this research studies
This research investigates how repeated head impacts, often experienced in contact sports, can affect the brain's protective membrane system, known as the pia-arachnoid complex (PAC). The study aims to develop a noninvasive tool to assess the performance of skull-brain decoupling, which may indicate subtle changes in the PAC due to these impacts. By comparing individuals with a history of repetitive head impacts to those without, the research seeks to identify early signs of injury that are not detectable with current imaging techniques. This could lead to better diagnosis and management of athletes at risk for concussion and other brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research include athletes who participate in contact sports and have experienced repetitive head impacts.
Not a fit: Patients who have not engaged in contact sports or have no history of head impacts may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new method for early detection of brain injuries in athletes, potentially preventing long-term damage.
How similar studies have performed: While the approach of assessing PAC changes through skull-brain decoupling is innovative, similar research has shown promise in identifying brain injuries through advanced imaging techniques.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Yin, Ziying — Mayo Clinic Rochester
- Study coordinator: Yin, Ziying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.