Detecting bladder cancer early using urine samples
Official title: Early detection of bladder cancer through urothelial cell enrichment and DNA flow cytometry
Funded at Johns Hopkins University · NIH-10851980 · Data updated 2026-11-12
This study is working on a new, easy way to spot bladder cancer early by looking at DNA in urine samples, making it more accurate and affordable for patients with bladder tumors.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $279,608 |
| NIH project number | 5K08CA276704-02 |
| Project ID | NIH-10851980 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have been referred for bladder cancer screening, particularly those presenting with blood in their urine.
✕Less likely to help
Patients who do not have symptoms or risk factors for bladder cancer may not benefit from this research.
What this research studies
This research focuses on improving the early detection of bladder cancer by developing a noninvasive method that analyzes DNA from urine samples. The approach involves enriching urothelial cells to enhance the accuracy of DNA sequencing, which can identify cancerous changes. By addressing challenges such as the dilution of tumor DNA and the high costs of current methods, this project aims to create a more effective and accessible screening tool for bladder cancer. Patients with known bladder tumors will provide urine samples to refine this innovative technique.
Why it matters
Potential benefit: If successful, this research could lead to a more accurate and less invasive method for early bladder cancer detection, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using urinary DNA for cancer detection, indicating that this approach may lead to significant advancements in bladder cancer screening.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Dudley, Jonathan Carl — Johns Hopkins University
- Study coordinator: Dudley, Jonathan Carl
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.