Detecting bladder cancer early using urine samples
Early detection of bladder cancer through urothelial cell enrichment and DNA flow cytometry
['FUNDING_CAREER'] · JOHNS HOPKINS UNIVERSITY · NIH-10851980
This study is working on a new, easy way to spot bladder cancer early by looking at DNA in urine samples, making it more accurate and affordable for patients with bladder tumors.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10851980 on ClinicalTrials.gov |
What this research studies
This research focuses on improving the early detection of bladder cancer by developing a noninvasive method that analyzes DNA from urine samples. The approach involves enriching urothelial cells to enhance the accuracy of DNA sequencing, which can identify cancerous changes. By addressing challenges such as the dilution of tumor DNA and the high costs of current methods, this project aims to create a more effective and accessible screening tool for bladder cancer. Patients with known bladder tumors will provide urine samples to refine this innovative technique.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been referred for bladder cancer screening, particularly those presenting with blood in their urine.
Not a fit: Patients who do not have symptoms or risk factors for bladder cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more accurate and less invasive method for early bladder cancer detection, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using urinary DNA for cancer detection, indicating that this approach may lead to significant advancements in bladder cancer screening.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUDLEY, JONATHAN CARL — JOHNS HOPKINS UNIVERSITY
- Study coordinator: DUDLEY, JONATHAN CARL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.