Detecting Barrett's Esophagus Early to Prevent Esophageal Cancer
A Clinical Trial of Cancer Prevention by Biomarker Based Detections of Barrett's Esophagus and Its Progression
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11020622
This study is looking for a new, easy way to find Barrett's esophagus, a condition that can lead to cancer, using a swallowable device and a special DNA test, so we can catch it early in people who might not have any symptoms.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11020622 on ClinicalTrials.gov |
What this research studies
This research focuses on finding new ways to detect Barrett's esophagus, a condition that can lead to esophageal cancer, before it becomes serious. It aims to use a non-invasive method involving a swallowable device and a special DNA test to identify patients who may not show symptoms of acid reflux. By catching Barrett's esophagus early, the research hopes to prevent its progression to cancer, which has a high mortality rate. Patients will be screened in a simple office procedure, making it accessible and less daunting than traditional endoscopic methods.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Barrett's esophagus, particularly those without symptoms of gastroesophageal reflux disease.
Not a fit: Patients who already have a confirmed diagnosis of Barrett's esophagus or esophageal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the number of esophageal cancer cases by enabling earlier detection and intervention.
How similar studies have performed: Previous research has shown promise in using biomarker-based detection methods for various cancers, suggesting potential success for this novel approach.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARKOWITZ, SANFORD D. — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: MARKOWITZ, SANFORD D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.