Detecting and understanding blood clots in living organisms
Direct Detection and Characterization of Thrombosis In Vivo
This study is working on a new way to spot and understand blood clots using special tools that can help doctors see them clearly in real-time, which could lead to better treatments for people with heart and brain conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10438599 on NIH RePORTER |
What this research studies
This research focuses on improving the detection and characterization of blood clots, which are critical in various cardiovascular and neurovascular conditions. By using specialized RNA aptamers that bind to coagulation proteins, the team aims to develop a new imaging technique that can visualize blood clots in real-time using advanced PET imaging. This approach will allow for better differentiation between new and old clots, potentially leading to more effective treatment strategies for patients experiencing thrombotic events. The research will be conducted in mouse models and later assessed in nonhuman primates to ensure its applicability in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for thrombosis, such as those with cardiovascular diseases or those recovering from surgery.
Not a fit: Patients who do not have any history of thrombotic events or related cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely diagnosis and treatment of blood clot-related conditions, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using aptamer-antidote pairs for thrombus detection, indicating that this approach could be a significant advancement in the field.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Tarantal, Alice F — University of California at Davis
- Study coordinator: Tarantal, Alice F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.