Detecting altered brain pH in early Alzheimer's disease using advanced MRI techniques
Altered pH in early Alzheimer's disease detected by creatine chemical exchange saturation transfer MRI
This study is looking at how changes in brain acidity can be spotted in people with early Alzheimer's disease using a special MRI scan, which could help doctors tell the difference between those with the disease and healthy individuals, making it easier to diagnose and understand Alzheimer's early on.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hugo W. Moser Res Inst Kennedy Krieger NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10337352 on NIH RePORTER |
What this research studies
This research investigates how changes in brain pH levels can be detected in individuals with early Alzheimer's disease using a specialized MRI technique called creatine chemical exchange saturation transfer. The study aims to identify pH as a potential early biomarker for Alzheimer's, which could help differentiate between those with the disease and healthy individuals. By focusing on the early stages of Alzheimer's, the research seeks to improve diagnostic accuracy and understanding of the disease's progression. Participants may undergo MRI scans to assess their brain chemistry and its relation to Alzheimer's pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are experiencing early symptoms of cognitive decline or have been diagnosed with mild cognitive impairment.
Not a fit: Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of Alzheimer's disease, allowing for timely interventions and better management of the condition.
How similar studies have performed: Previous studies have shown promise in using brain pH as a biomarker for neurodegenerative diseases, suggesting that this approach may yield valuable insights into Alzheimer's disease.
Where this research is happening
Baltimore, United States
- Hugo W. Moser Res Inst Kennedy Krieger — Baltimore, United States (Active)
Researchers
- Principal investigator: Xu, Jiadi — Hugo W. Moser Res Inst Kennedy Krieger
- Study coordinator: Xu, Jiadi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.