Detect early signs of high-grade ovarian cancer
Project 1: Diagnose high-grade ovarian serous carcinoma precursors and occult tumors
This study is looking for better ways to spot early signs of ovarian cancer, especially in the fallopian tubes, by finding specific genetic clues that can help doctors catch it sooner for women who are at higher risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10935406 on NIH RePORTER |
What this research studies
This research focuses on improving the detection of early-stage ovarian cancer and its precursors, specifically in the fallopian tubes. It aims to identify specific genetic markers and patterns that indicate the presence of serous tubal intraepithelial carcinoma (STIC) and high-grade serous carcinoma (HGSC). By analyzing epithelial cells collected from the tubes and ovaries, the study seeks to enhance diagnostic accuracy beyond current methods, which often miss these subtle lesions. This could lead to earlier interventions for women at high risk of developing ovarian cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are women at high risk for ovarian cancer, particularly those with genetic predispositions or family histories of the disease.
Not a fit: Patients who do not have a high risk for ovarian cancer or those who have already been diagnosed with advanced-stage ovarian cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of ovarian cancer, potentially improving treatment outcomes and survival rates.
How similar studies have performed: Other research has shown promise in using genetic markers for early cancer detection, suggesting that this approach could be effective.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Papadopoulos, Nickolas — Johns Hopkins University
- Study coordinator: Papadopoulos, Nickolas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.