Detailed brain maps of areas, networks, and connections
Next Generation Multi-modal Human Connectome Project Atlases
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-11241169
Researchers will build high-resolution brain maps of areas, networks, and white-matter connections to help understand Alzheimer's disease and aging in adults.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11241169 on ClinicalTrials.gov |
What this research studies
This project uses high-resolution Human Connectome Project brain scans and precise imaging methods to create three integrated atlases: overlapping weighted grey-matter functional networks, detailed white-matter tracts with their grey-matter targets, and an expanded map that includes non-neocortical areas. The team will compare these new, data-driven maps to traditional atlases and prior anatomy studies to highlight differences and improvements. Automated methods will be developed so the atlases can be regenerated for new people and used to measure imaging-derived brain features across the whole brain. The atlases are intended to be useful for researchers and clinicians, for example in planning neurosurgery or tracking brain changes in Alzheimer's and related dementias.
Who could benefit from this research
Good fit: Adults with Alzheimer's disease or related dementias, as well as older adults or healthy volunteers who contribute high-resolution brain scans, would be relevant to this work or future linked studies.
Not a fit: People looking for immediate new treatments or therapies are unlikely to benefit directly, since this project focuses on building and validating imaging maps rather than testing interventions.
Why it matters
Potential benefit: If successful, the work could give doctors and researchers more precise brain maps to improve imaging interpretation, monitoring of disease, and surgical planning for people with Alzheimer's and other brain conditions.
How similar studies have performed: This builds on successful Human Connectome Project atlases and neuroimaging methods, but extends them into novel weighted network maps, white-matter tract atlases, and non-neocortical areas that are less well mapped.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GLASSER, MATTHEW FREDERICK — WASHINGTON UNIVERSITY
- Study coordinator: GLASSER, MATTHEW FREDERICK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome