Designing special proteins to understand diseases like degenerative neurologic disorders
Official title: Understanding Evolution of Protein Function Through Design
Funded at Baylor University · NIH-11197600 · Data updated 2026-11-12
This work explores how specially designed proteins called CAMPs can help us understand diseases like degenerative neurologic disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor University NIH-funded |
| Lab location | 1 site (Waco, United States) |
| Project start | August 1, 2016 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $385,000 |
| NIH project number | 5R35GM119634-10 |
| Project ID | NIH-11197600 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with degenerative neurologic disorders, particularly those linked to amyloid proteins, may find this foundational research relevant to future treatments.
✕Less likely to help
Patients not affected by degenerative neurologic disorders or amyloid-related conditions would not directly benefit from this specific research.
What this research studies
This research focuses on designing short proteins, known as Catalytic Amyloid-forming Peptides (CAMPs), which can both self-assemble and speed up chemical reactions. Our goal is to understand the detailed structure and mechanism behind the high efficiency of these CAMPs and to improve their ability to target specific reactions. We also aim to create new catalytic materials using these amyloid structures and develop more complex CAMPs with multiple functions. A deeper understanding of these amyloid proteins could provide crucial insights into how they contribute to conditions such as degenerative neurologic disorders.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of amyloid-related diseases and potentially new ways to develop treatments.
How similar studies have gone: This research builds upon existing observations about catalytic amyloid peptides while also developing new experimental approaches and materials.
Where this research is happening
-
Baylor University
Waco, United States Active
Researchers
- Principal investigator: Korendovych, Ivan V — Baylor University
- Study coordinator: Korendovych, Ivan V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.