Designing new iron-based catalysts for carbonyl-olefin metathesis
Official title: Mechanism-Based Design of Iron-Mediated Carbonyl-Olefin Metathesis Protocols
Funded at Loyola University of Chicago · NIH-11361305 · Data updated 2026-11-12
A scientist team is designing smarter iron-containing catalysts to enable carbonyl-olefin metathesis in making medicinal compounds.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $484,636 |
| NIH project number | 1R15GM164970-01 |
| Project ID | NIH-11361305 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are researchers or clinicians interested in applying advanced catalytic methods to synthesize drugs and related compounds.
✕Less likely to help
Patients not involved in drug development or those not seeking medicines produced via catalysis may see limited direct benefit.
What this research studies
This project uses synthetic chemistry, spectroscopy, kinetics, and computer modeling to understand how ligands and substrates influence iron-catalyzed carbonyl-olefin metathesis. By mapping how the catalyst rests and turns over, the team hopes to design more effective catalysts. The work combines bench experiments with computational insights to build a general model of how the reaction proceeds. The ultimate goal is to expand access to this catalytic method for creating medicinally valuable molecules.
Why it matters
Potential benefit: If successful, patients could benefit from more efficient routes to important medicines made with iron-based catalysts.
How similar studies have gone: Similar catalytic designs have advanced understanding of metathesis, with ongoing progress in catalyst optimization.
Where this research is happening
-
Loyola University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Devery, James John — Loyola University of Chicago
- Study coordinator: Devery, James John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.