Designing new immunogens to fight HIV-1 using SHIV-infected monkeys
SHIV-guided design of novel HIV-1 fusion peptide immunogens
This study is looking at how monkeys infected with a virus similar to HIV can develop strong antibodies that fight the virus, which could help scientists create better vaccines for people with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11059866 on NIH RePORTER |
What this research studies
This research investigates how SHIV-infected rhesus macaques develop broadly neutralizing antibodies against HIV-1, which can inform the design of new immunogens for potential vaccines. By analyzing the immune responses in these monkeys, the researchers aim to identify critical steps in the elicitation of these antibodies, including the priming of B cell precursors and the boosting of immune responses. The study will involve creating novel SHIVs to guide the design of immunogens that can effectively stimulate the immune system to produce protective antibodies against HIV-1.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for HIV infection or those living with HIV who may benefit from improved vaccine strategies.
Not a fit: Patients who are not at risk for HIV or those who are already effectively managing their HIV with current treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines against HIV-1, potentially reducing the incidence of AIDS.
How similar studies have performed: Previous research has shown promise in using animal models to guide vaccine development, suggesting that this approach could yield significant advancements in HIV vaccine strategies.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Shaw, George M — University of Pennsylvania
- Study coordinator: Shaw, George M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.