Designing Advanced Antioxidant Molecules for Chronic Diseases
Official title: Expanding the Facets of Multi-Functional Antioxidant Molecules Through Computational Design and Biological Tools
Funded at Texas Christian University · NIH-11125102 · Data updated 2026-11-12
This project aims to create new small molecules that can control oxidative stress, a common factor in many chronic diseases like Alzheimer's, to protect cells from damage.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Christian University NIH-funded |
| Lab location | 1 site (Fort Worth, United States) |
| Project start | June 1, 2018 |
| Project end | July 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $406,882 |
| NIH project number | 2R15GM123463-03 |
| Project ID | NIH-11125102 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is not directly recruiting patients but aims to benefit individuals with chronic diseases like Alzheimer's, macular degeneration, kidney disease, Friedreich’s ataxia, cancer, and inflammatory bowel syndrome in the future.
✕Less likely to help
Patients without conditions linked to chronic oxidative stress would not directly benefit from this specific research.
What this research studies
Oxidative stress plays a big role in many serious health conditions, including Alzheimer's disease, macular degeneration, and certain cancers. While these diseases are often treated differently, they share this common problem of oxidative stress. Our goal is to develop special small molecules that can manage oxidative stress and prevent harm to your cells and other important body structures. These molecules work in several ways, including boosting your body's natural antioxidant defenses and mimicking protective enzymes. We hope to show that these molecules can predictably control oxidative stress, offering a new way to prevent or slow down disease progression.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that prevent or halt the progression of diseases linked to oxidative stress, potentially improving long-term patient outcomes.
How similar studies have gone: While the concept of targeting oxidative stress is known, this project focuses on developing a novel class of multi-functional small molecules with unique catalytic pathways.
Where this research is happening
-
Texas Christian University
Fort Worth, United States Active
Researchers
- Principal investigator: Green, Kayla N — Texas Christian University
- Study coordinator: Green, Kayla N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.