Designing Advanced Antioxidant Molecules for Chronic Diseases
Expanding the Facets of Multi-Functional Antioxidant Molecules Through Computational Design and Biological Tools
['FUNDING_R15'] · TEXAS CHRISTIAN UNIVERSITY · NIH-11125102
This project aims to create new small molecules that can control oxidative stress, a common factor in many chronic diseases like Alzheimer's, to protect cells from damage.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS CHRISTIAN UNIVERSITY (nih funded) |
| Locations | 1 site (FORT WORTH, UNITED STATES) |
| Trial ID | NIH-11125102 on ClinicalTrials.gov |
What this research studies
Oxidative stress plays a big role in many serious health conditions, including Alzheimer's disease, macular degeneration, and certain cancers. While these diseases are often treated differently, they share this common problem of oxidative stress. Our goal is to develop special small molecules that can manage oxidative stress and prevent harm to your cells and other important body structures. These molecules work in several ways, including boosting your body's natural antioxidant defenses and mimicking protective enzymes. We hope to show that these molecules can predictably control oxidative stress, offering a new way to prevent or slow down disease progression.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals with chronic diseases like Alzheimer's, macular degeneration, kidney disease, Friedreich’s ataxia, cancer, and inflammatory bowel syndrome in the future.
Not a fit: Patients without conditions linked to chronic oxidative stress would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that prevent or halt the progression of diseases linked to oxidative stress, potentially improving long-term patient outcomes.
How similar studies have performed: While the concept of targeting oxidative stress is known, this project focuses on developing a novel class of multi-functional small molecules with unique catalytic pathways.
Where this research is happening
FORT WORTH, UNITED STATES
- TEXAS CHRISTIAN UNIVERSITY — FORT WORTH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GREEN, KAYLA N — TEXAS CHRISTIAN UNIVERSITY
- Study coordinator: GREEN, KAYLA N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease